Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads
E. Hallumi, R. Shalah, W.-L. Lo, J. Corso, I. Oz, D. Beach, S. Wittman, A. Isenberg, M. Sela, H. Urlaub, A. Weiss, D. Yablonski
This study identifies Itk-mediated phosphorylation sites on SLP-76 and Gads that regulate TCR/CD28 costimulation-induced transcriptional responses.
bioRxiv · Sep 11, 2020Immunology