Author

W.-L. Lo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

A. E. van Vlimmeren· 1 shared A. Isenberg· 1 shared A. Weiss· 1 shared C. A. Chartier· 1 shared C. T. Ho· 1 shared C.-H. Hsu· 1 shared D. Beach· 1 shared D. Karandur· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. E. van Vlimmeren

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3 papers

Recent·Most cited

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain

A. E. van Vlimmeren, R. Voleti, C. A. Chartier, Z. Jiang, D. Karandur, P. A. Humphries, W.-L. Lo, N. H. Shah

This paper investigates the T42A mutation in SHP2, showing it alters ligand-binding specificity in the N-terminal SH2 domain, leading to biased activation and enhanced signaling.

bioRxiv · Jul 10, 2023Biochemistry

Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads

E. Hallumi, R. Shalah, W.-L. Lo, J. Corso, I. Oz, D. Beach, S. Wittman, A. Isenberg, M. Sela, H. Urlaub, A. Weiss, D. Yablonski

This study identifies Itk-mediated phosphorylation sites on SLP-76 and Gads that regulate TCR/CD28 costimulation-induced transcriptional responses.

bioRxiv · Sep 11, 2020Immunology

Ran GTPase regulates non-centrosomal microtubule nucleation and is transported by actin waves towards the neurite tip.

Y.-A. Huang, C.-H. Hsu, H.-C. Chiu, C. T. Ho, W.-L. Lo, E. Hwang

This study identifies Ran GTPase as a regulator of non-centrosomal microtubule nucleation in neurons, showing that RanGTP is transported by actin waves to neurite tips.

bioRxiv · Jun 28, 2019 · PreprintCell Biology