Direct Measure of DNA Damage in Huntington Disease Reveals Elevated Oxidative Genotoxic Stress and Dysfunctional DNA Repair
Carlos Barba Bazan, Samantha R Laville-Dupuy, Maya Klepfish, J. Cousineau, Tamara Maiuri, Christina Yi Peng, Elizabeth J. Osterlund, Melanie Alpaugh, Ray Truant
This study uses RADD to directly measure oxidative DNA damage in HD cells, revealing elevated DNA damage and dysfunctional DDR pathways.
bioRxiv · Nov 21, 2025 · PreprintCell Biology