Ray Truant

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

This study uses RADD to directly measure oxidative DNA damage in HD cells, revealing elevated DNA damage and dysfunctional DDR pathways.

This paper develops a high-content system to quantify mitochondrial morphology in patient-derived human cells, finding Huntington Disease fibroblasts have smaller, more circular mitochondria indicating increased fission.

This paper describes using microbeads to improve autofocus accuracy in brightfield microscopy for long-term live cell imaging.

The paper identifies a deficient PAR response in Huntington disease patients, suggesting a potential therapeutic target for early intervention.