Melanie Alpaugh

The paper designs peptide inhibitors targeting fungal peptidases to reduce virulence and resistance without harming host cells, showing efficacy in vitro and in vivo.

This study uses RADD to directly measure oxidative DNA damage in HD cells, revealing elevated DNA damage and dysfunctional DDR pathways.

This study identifies vessel-type-specific vascular barrier dysfunction in Huntington's disease and shows partial rescue with an S1PR1 agonist.

The paper demonstrates that CRISPR-Cas9 nickase can contract CAG/CTG repeats in patient-derived cells and improve molecular and behavioral phenotypes in Huntington's disease.