Decrowding Expansion Pathology: Unmasking Previously Invisible Nanostructures and Cells in Intact Human Brain Pathology Specimens
P. A. Valdes, C.-C. Yu, J. L. Aronson, Y. Zhao, J. D. Bernstock, D. Bhere, B. An, M. S. Viapiano, K. Shah, E. A. Chiocca, E. S. Boyden
The paper introduces dExPath, an expansion microscopy variant that improves immunostaining in human brain pathology specimens by expanding proteins and reducing autofluorescence, revealing previously invisible disease markers.
bioRxiv · Dec 5, 2021 · PreprintBioengineering