Author

E. A. Chiocca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. T. Farrar· 2 shared H. Ito· 2 shared H. Nakashima· 2 shared O. Perlman· 2 shared A. A. Gilad· 1 shared A. Balan· 1 shared A. Boire· 1 shared A. Stafford· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

C. T. Farrar

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Author profile →

6 papers

Recent·Most cited

A generative reference grammar of healthy TCR repertoires reveals cancer-associated immune remodeling

A. Balan, Y. Elhanati, K. E. Meza Landeros, M. De Almeida Mendes, J. Lai, S. S. A. Zaidi, M. Unal, B. Y. S. Kim, C.-H. G. Lucas, E. Runco, V. K. Puduvalli, J. Gantchev, C. A. Whittaker, P. Sharma, V. Tabar, , R. Karchin

CRAFT, a transformer model, learns a generative grammar of healthy TCR repertoires to detect cancer-associated immune remodeling through structured deviations in sequence space.

bioRxiv · Jun 20, 2026 · PreprintCancer Biology

STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models

G. Berger, E. H. Knelson, J. L. Jimenez-Macias, M. O. Nowicki, S. Han, P. H. Lizotte, K. Adu-Berchie, A. Stafford, N. Dimitrikakis, E. A. Chiocca, D. J. Mooney, D. A. Barbie, S. E. Lawler

This study shows that STING activation in glioblastoma models enhances immune responses and NK cell-mediated tumor regression, with long-term survival benefits in murine models.

bioRxiv · Feb 28, 2022 · PreprintCancer Biology

Decrowding Expansion Pathology: Unmasking Previously Invisible Nanostructures and Cells in Intact Human Brain Pathology Specimens

P. A. Valdes, C.-C. Yu, J. L. Aronson, Y. Zhao, J. D. Bernstock, D. Bhere, B. An, M. S. Viapiano, K. Shah, E. A. Chiocca, E. S. Boyden

The paper introduces dExPath, an expansion microscopy variant that improves immunostaining in human brain pathology specimens by expanding proteins and reducing autofluorescence, revealing previously invisible disease markers.

bioRxiv · Dec 5, 2021 · PreprintBioengineering

AI boosted molecular MRI for apoptosis detection in oncolytic virotherapy

O. Perlman, H. Ito, K. Herz, N. Shono, H. Nakashima, M. Zaiss, E. A. Chiocca, O. Cohen, M. S. Rosen, C. T. Farrar

This paper introduces an AI-enhanced molecular MRI technique to detect apoptosis in oncolytic virotherapy, showing early detection of apoptotic response in a glioblastoma model and clinical validation in a human subject.

Nature Biomedical Engineering · Nov 11, 2021Peer-reviewedBiophysics

BTP-7, a novel peptide for therapeutic targeting of malignant brain tumors

N. von Spreckelsen, Y. Ghotmi, C. Fadzen, J. Wolfe, C. Farquhar, N. Hartrampf, S. Bergmann, M. Zdioruk, J. R. Wasserburg, E. Murrell, F. Bononi, L. Luyt, M. Lamfers, K. Ligon, E. A. Chiocca, , C.-F. Cho

This study identifies BTP-7, a peptide that targets dg-Bcan in glioma cells, enhancing drug delivery and survival in tumor-bearing mice.

bioRxiv · May 21, 2020 · PreprintBioengineering

Redesigned Reporter Gene for Improved Proton Exchange-based Molecular MRI Contrast

O. Perlman, H. Ito, A. A. Gilad, M. T. McMahon, E. A. Chiocca, H. Nakashima, C. T. Farrar

The paper redesigns a reporter gene to improve CEST MRI contrast by reducing DNA recombination and enhancing stability and sensitivity.

bioRxiv · Apr 21, 2020Bioengineering