LOSS OF UBIQUITIN LIGASE STUB1 AMPLIFIES IFNγ-R1/JAK1 SIGNALING AND SENSITIZES TUMORS TO IFNγ
G. Apriamashvili, D. W. Vredevoogd, O. Krijgsman, O. B. Bleijerveld, M. A. Ligtenberg, B. de Bruijn, J. Boshuizen, D. D'Empaire Altimari, N. L. Visser, J. D. Londino, M. Altelaar, D. S. Peeper
This study shows that loss of STUB1 enhances IFNγ signaling and sensitizes tumors to IFNγ, suggesting STUB1 inhibition combined with PD-1 blockade could improve cancer immunotherapy.
bioRxiv · Jul 7, 2020 · PreprintCancer Biology