M. Altelaar

An "alert state" ribosome population acts as a master regulator of cytokine mediated processes

The paper identifies an 'alert-state' ribosome subpopulation (ASRs) that regulates cytokine-mediated processes by preferentially translating key mRNAs involved in immune responses.

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator

This study uses a CRISPR screen to identify genes critical for macrophage-mediated killing of prostate cancer cells, revealing AR as an immunomodulator that promotes resistance to macrophage attack.

Phosphoprotein dynamics of interacting tumor and T cells by HySic

This paper introduces HySic, a method to quantify protein and phosphorylation dynamics between interacting tumor and T cells, revealing the RHO/RAC/PAK1 pathway's activation and its role in T cell-mediated tumor killing.

Predicting treatment outcome using kinome activity profiling in HER2+ breast cancer biopsies

This study uses kinase activity profiling in HER2+ breast cancer biopsies to predict treatment outcomes and identify resistance mechanisms.

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

This study shows that extracellular vesicles from kidney tubular cells enhance tubuloid maturation by increasing transport protein expression and triggering key biological pathways.

Complementing the EGFR dynamic interactome using live-cell proximity labeling

This study uses APEX2 proximity labeling to map EGFR interactions and phosphorylation dynamics over time, revealing differences in early signaling kinetics between TGF- and EGF.

Capturing the signalling dynamics of the MAPK-AKT-mTOR pathway in a single targeted phosphoproteomics assay

This paper introduces a targeted phosphoproteomics assay to study the dynamic phosphorylation of the MAPK-AKT-mTOR pathway with high sensitivity and throughput.

Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at the base of primary cilia and suppresses ciliary elongation

This study identifies Angiomotin isoform 2 as a KIF13B interactor that recruits PALS1 to the base of primary cilia, regulating ciliary length by modulating KIF13B cargo binding.

Single-embryo phosphoproteomics reveals the importance of intrinsic disorder in cell cycle dynamics

The paper uses single-embryo phosphoproteomics to show that phosphorylation of intrinsically disordered proteins by cell cycle kinases drives switch-like mitotic reorganization.

The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy

This study shows the EMCV Leader protein promotes EV-mediated virus release by inducing secretory autophagy, revealing a new role for non-structural viral proteins in non-lytic release.

Multistep mechanism of DNA replication-coupled G-quadruplex resolution

The paper identifies a three-step mechanism for resolving G-quadruplex structures during DNA replication using Xenopus egg extracts.

The lysosomal V-ATPase B1 subunit in renal proximal tubule is linked to nephropathic cystinosis

The paper shows that ATP6V1B1 deficiency in renal proximal tubule cells causes cystine accumulation and autophagy activation, linking it to cystinosis.

LOSS OF UBIQUITIN LIGASE STUB1 AMPLIFIES IFNγ-R1/JAK1 SIGNALING AND SENSITIZES TUMORS TO IFNγ

This study shows that loss of STUB1 enhances IFNγ signaling and sensitizes tumors to IFNγ, suggesting STUB1 inhibition combined with PD-1 blockade could improve cancer immunotherapy.

Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis

This study identifies alpha-ketoglutarate as a key metabolite in cystinosis and shows that combining cysteamine with bicalutamide corrects proximal tubule defects in cell models and zebrafish.

Glucocorticoids regulate cancer cell dormancy

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.

Combined EGFR and ROCK inhibition in TNBC leads to cell death via impaired autophagic flux

This study shows that combined EGFR and ROCK inhibition in TNBC causes cell death by blocking autophagic flux, leading to autophagic vacuole accumulation.

Fibril formation rewires interactome of the Alzheimer protein Tau by π-stacking

This study shows that Tau fibrils use π-stacking by arginine side chains to alter protein interactions, attracting specific proteins linked to Alzheimer's and that Hsp90 can suppress these interactions.

Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1

The paper identifies an evolutionarily-conserved interaction between HDAC1 and DOT1L that influences H3K79 methylation and contributes to thymic lymphoma development.