J. W. Mellors

Reduction of the HIV-1 reservoir in T cells from persons with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells ex vivo

This study shows that expanded natural killer cells can reduce HIV-1 reservoirs in treated patients when combined with latency-reversing agents and broadly neutralizing antibodies.

Discovery and pre-clinical evaluation of antibodies to the NKG2A inhibitory receptor

The paper discovers and evaluates two fully human antibodies that inhibit NKG2A, an inhibitory receptor on NK and CD8+ T cells, enhancing anti-cancer immune responses.

Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

Emerging SARS-CoV-2 Variants of Concern: Spike Protein Mutational Analysis and Epitope for Broad Neutralization

This study identifies a broadly neutralizing antibody fragment and analyzes spike protein mutations in SARS-CoV-2 variants to understand their structural and functional impacts on antibody evasion.

Neutralization of European, South African, and United States SARS-CoV-2 mutants by a human antibody and antibody domains

The paper evaluates an antibody domain's ability to neutralize SARS-CoV-2 variants with mutations in the RBD, showing it neutralizes the triple mutation variant but not others.

Integration in or Near Oncogenes Plays Only a Minor Role in Determining the in Vivo Distribution of HIV Integration Sites Before or During Suppressive Antiretroviral Therapy

The paper compares HIV integration site distributions in vivo and in vitro to assess the role of oncogene integration in viral persistence during ART.

Early Emergence and Long-Term Persistence of HIV-Infected T Cell Clones in Children

This study identifies early emergence and long-term persistence of HIV-infected T cell clones in children on antiretroviral therapy, with proviral integration in proto-oncogenes.

Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

This study shows that HIV-1 envelope glycoprotein mutations can confer broad antiretroviral resistance through cell-cell transmission and structural changes, independent of target-gene mutations.

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes

This study uses dendritic cells to focus CD8+ T cell responses on conserved and topologically important HIV epitopes to prevent immune escape.

Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models

This study rapidly identifies a potent human monoclonal antibody against SARS-CoV-2 that neutralizes the virus in animal models and shows promise for therapeutic use.

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

This study assesses the precision and repeatability of HIV-1 latent reservoir size measurements using QVOA across labs and storage conditions, finding assay variability and supporting frozen storage.