Author

J. Denu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. L. Nielsen· 1 shared C. A. Olsen· 1 shared G. H. Peters· 1 shared I. Jensen· 1 shared J. E. Bolding· 1 shared J. M. Rogers· 1 shared L. A. Ryberg· 1 shared M. Klein· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. L. Nielsen

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Author profile →

3 papers

Recent·Most cited

Fluorogenic Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7

J. E. Bolding, A. L. Nielsen, I. Jensen, T. N. Hansen, L. A. Ryberg, S. T. Jameson, P. Harris, G. H. Peters, J. Denu, J. M. Rogers, C. A. Olsen

This study develops fluorogenic assays and cyclic peptide inhibitors to probe SIRT7 activity and selectivity, revealing its monomeric structure and substrate preferences.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

Potent activation of NAD+-dependent deacetylase Sirt7 by nucleosome binding

V. I. Kuznetsov, W. Liu, M. Klein, J. Denu

This study identifies nucleosome binding as a key activator of Sirt7 deacetylase activity, revealing its efficiency and limitations in chromatin context.

bioRxiv · May 11, 2022Biochemistry

Short-chain fatty acids activate acetyltransferase p300

S. Thomas, J. Denu

This study shows that propionate and butyrate activate the acetyltransferase p300, challenging the belief that SCFAs mainly regulate chromatin by inhibiting HDACs.

bioRxiv · Jul 21, 2021Biochemistry