Author

J. M. Rogers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. C. Blacklow· 3 shared J. C. Aster· 2 shared A. H.-W. Yeh· 1 shared A. L. Nielsen· 1 shared A. N. Hoofnagle· 1 shared A. P. Martin· 1 shared A. P. South· 1 shared C. A. Olsen· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersCell Biology

S. C. Blacklow

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry

L. Tveriakhina, G. Scanavachi, E. D. Egan, R. B. D. C. Correia, A. P. Martin, J. M. Rogers, J. S. Yodh, J. C. Aster, T. Kirchhausen, S. C. Blacklow

This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

Fluorogenic Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7

J. E. Bolding, A. L. Nielsen, I. Jensen, T. N. Hansen, L. A. Ryberg, S. T. Jameson, P. Harris, G. H. Peters, J. Denu, J. M. Rogers, C. A. Olsen

This study develops fluorogenic assays and cyclic peptide inhibitors to probe SIRT7 activity and selectivity, revealing its monomeric structure and substrate preferences.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

De novo design of high-affinity protein binders to bioactive helical peptides

S. Vazquez Torres, P. J. Y. Leung, I. D. Lutz, P. Venkatesh, J. L. Watson, F. Hink, H.-H. Huynh, A. H.-W. Yeh, D. Juergens, N. R. Bennett, A. N. Hoofnagle, E. Huang, M. J. MacCoss, M. Exposit, G. R. Lee, , D. Baker

This paper designs high-affinity protein binders for bioactive helical peptides using deep learning and generative models, achieving picomolar affinity without experimental optimization.

bioRxiv · Dec 10, 2022 · PreprintBioengineering

Targeted degradation of the oncogenic phosphatase SHP2

V. Vemulapalli, K. A. Donovan, T. Seegar, J. M. Rogers, M. Bae, R. Lumpkin, R. Cao, M. Henke, E. S. Fischer, G. Cuny, S. C. Blacklow

This paper develops a SHP2 PROTAC that degrades SHP2 in leukemic cells, inhibits MAPK signaling, and suppresses cancer growth.

bioRxiv · Jun 2, 2021 · PreprintBiochemistry

Mitotic checkpoint gene expression is tuned by coding sequences

E. Esposito, D. E. Weidemann, J. M. Rogers, C. M. Morton, E. K. D. Baybay, J. Chen, S. Hauf

The paper shows that SAC gene expression in fission yeast is fine-tuned through codon usage and mRNA/protein half-life strategies to ensure proper checkpoint function.

bioRxiv · Apr 30, 2021Cell Biology

IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation

L. Pan, M. E. Lemieux, T. Thomas, J. M. Rogers, W. Lee, C. Johnson, L. Sholl, A. P. South, J. A. Marto, G. O. Adelmant, S. C. Blacklow, J. C. Aster

The paper identifies IER5 as a Notch-induced DNA-damage response gene required for squamous cell differentiation and shows its interaction with PP2A subunit PPP2R2A.

bioRxiv · Apr 21, 2020Cancer Biology