Central Nervous System Delivery and Biodistribution Analysis of an Antibody-Enzyme Fusion for the Treatment of Lafora Disease
G. L. Austin, Z. R. Simmons, J. E. Klier, B. L. Hodges, R. Shaffer, T. R. McKnight, J. R. Pauly, D. Armstrong, C. W. Vander Kooi, M. S. Gentry
This study evaluates the cerebral delivery and biodistribution of VAL-0417, an antibody-enzyme fusion for Lafora disease, showing intracerebroventricular administration is most effective.
bioRxiv · Jun 14, 2019Bioengineering