M. S. Gentry

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

This study investigates the role of TgLaforin, a glucan phosphatase, in Toxoplasma gondii by showing its impact on glucan metabolism, virulence, and bradyzoite survival during chronic infection.

In Situ Microwave Fixation to Define the Terminal Rodent Brain Metabolome

This study uses microwave fixation to preserve brain metabolites in mice, showing reduced glucose metabolism in diabetic models and altered metabolic enzyme expression.

An empirical pipeline for personalized diagnosis of Lafora disease mutations

This paper develops an empirical pipeline to classify EPM2A mutations in Lafora disease by analyzing their functional impact in vitro, linking specific mutations to clinical outcomes.

Generation and characterization of a laforin nanobody inhibitor

This study generates and characterizes laforin nanobodies to inhibit its catalytic activity and better understand its role in Lafora disease.

Compartmentalized glycogenolysis regulates lung cancer transcription

This study identifies nuclear glycogenolysis as a regulator of histone acetylation and transcription in lung cancer through malin-mediated glycogen phosphorylase translocation.

Central Nervous System Delivery and Biodistribution Analysis of an Antibody-Enzyme Fusion for the Treatment of Lafora Disease

This study evaluates the cerebral delivery and biodistribution of VAL-0417, an antibody-enzyme fusion for Lafora disease, showing intracerebroventricular administration is most effective.

Gas-chromatography coupled mass spectrometry for rapid and sensitive quantitation of glucose and glucose phosphates derived from glycogen

The paper introduces a gas-chromatography coupled mass spectrometry method to quantify glucose and glucose phosphates in glycogen, showing higher glycogen levels in liver and more phosphate esters in skeletal muscle.