Influenza-induced oxidative stress sensitizes lung cells to bacterial toxin-mediated necroptosis
N. Gonzalez-Juarbe, A. N. Riegler, A. S. Jureka, R. P. Gilley, J. Brand, J. E. Trombley, N. R. Scott, P. H. Dube, C. M. Petit, K. S. Harrod, C. J. Orihuela
This paper shows that influenza virus increases lung cell sensitivity to bacterial toxin-induced necroptosis through oxidative stress, suggesting necroptosis inhibitors as potential treatments for severe infections.
bioRxiv · Feb 20, 2020Microbiology