C. J. Orihuela

PspA-mediated aggregation protects Streptococcus pneumoniae against desiccation on fomites

This study shows PspA-mediated aggregation of Streptococcus pneumoniae enhances desiccation survival on fomites and transmission to new hosts.

Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell model reveals differential host glycoconjugate uptake and metabolism

This study uses ex vivo transcriptomics to show that influenza A virus infection enhances pneumococcal growth and alters bacterial metabolism in human lung epithelial cells.

Engineered superinfective Pf phage prevents dissemination of Pseudomonas aeruginosa in a mouse burn model

The paper engineers a superinfective Pf phage to prevent Pseudomonas aeruginosa dissemination in burn wounds, achieving bacterial clearance and survival in mice.

Pseudomonas aeruginosa synthesizes the autoinducers of its oxylipin-dependent quorum sensing system extracellularly

This study shows that Pseudomonas aeruginosa synthesizes oxylipin autoinducers extracellularly via the Xcp type II secretion system, revealing a novel mechanism for quorum sensing and biofilm formation.

Capsule protects against intracellular killing and enables vascular endothelial cell translocation during invasive pneumococcal disease

This study shows that pneumococcal capsule protects bacteria from oxidative stress in host cells and enhances disease severity by promoting intracellular survival and translocation.

Influenza-induced oxidative stress sensitizes lung cells to bacterial toxin-mediated necroptosis

This paper shows that influenza virus increases lung cell sensitivity to bacterial toxin-induced necroptosis through oxidative stress, suggesting necroptosis inhibitors as potential treatments for severe infections.