Author

J. E. Visvader

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

A. Strasser· 2 shared M. J. Herold· 2 shared M. Milevskiy· 2 shared S. Diepstraten· 2 shared Z. Wang· 2 shared A. Bhutkar· 1 shared A. J. Kueh· 1 shared A. Jetten· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. Strasser

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Author profile →

4 papers

Recent·Most cited

Towards resolution of the intron retention paradox in breast cancer

J. S. Shah, M. Milevskiy, V. Petrova, A. Y. Au, J. J. L. Wong, J. E. Visvader, U. Schmitz, J. E. J. Rasko

This study investigates intron retention (IR) patterns in breast cancer and other cancers, finding that reduced IR in breast tumors correlates with poor prognosis and is linked to factors like cell proliferation and RBP expression.

bioRxiv · Mar 4, 2022Cancer Biology

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

M. A. Potts, S. Mizutani, Y. Deng, S. Vaidyanathan, K. Ting, G. Giner, S. Shruti, Y. Liao, S. Diepstraten, A. J. Kueh, M. Pal, G. Healey, L. Tai, Z. Wang, C. Koenig, , M. J. Herold

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

M. M. Wilson, C. Callens, M. Le Gallo, S. Mironov, Q. Ding, A. Salamagnon, T. Chavarria, A. Peasah, A. Bhutkar, S. Martin, F. Godey, P. Tas, A. Jetten, J. E. Visvader, R. Weinberg, , V. Guen

This study identifies an EMT-primary cilium-GLIS2 signaling axis that regulates mammary stem cell properties and claudin-low breast tumorigenesis.

bioRxiv · Dec 29, 2020Cell Biology

Loss of mutant TP53 does not impair the sustained proliferation, survival ormetastasis of diverse cancer cells

Z. Wang, F. Vailllant, C. Chang, C. Riffkin, E. Lieschke, S. Diepstraten, D. Huang, J. E. Visvader, M. J. Herold, G. Kelly, A. Strasser

This study shows that removing mutant TP53 does not affect cancer cell survival, proliferation, or metastasis, suggesting GOF effects are not universally required for malignant growth.

bioRxiv · Mar 30, 2020 · PreprintCancer Biology