A. J. Kueh

Relative importance of MCL-1's Anti-Apoptotic versus Non-Apoptotic Functions in vivo

This study replaces MCL-1 with other anti-apoptotic proteins in mice to determine the relative importance of MCL-1's anti-apoptotic versus non-apoptotic functions in development and physiology.

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

This study shows that deleting TFAP4 in E-MYC transgenic mice accelerates lymphoma development by blocking B cell differentiation.

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

This study shows that cleavage of cFLIP by Caspase-8 limits cell death during viral infection and tissue injury, promoting tissue repair.

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

This study shows that MLKL deficiency reduces age-related sterile inflammation in mice by preserving lymphocyte levels and reducing inflammatory infiltrates in tissues.

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

Severe dysregulation of TNF expression leads to multiple inflammatory diseases and embryonic death

The paper identifies a new regulatory element in the Tnf 3UTR that cooperates with existing elements to downregulate TNF expression and prevent autoimmune diseases, and shows excessive TNF causes embryonic death.

An Erg driven transcriptional program controls B-lymphopoiesis

This study identifies Erg as a critical transcription factor initiating B-lymphopoiesis by regulating gene networks essential for B-cell development and V(D)J recombination.