G. Kelly

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of oesophageal cancer

The paper investigates how CDKN2A and other 9p21 gene losses influence oesophageal cancer progression, finding context-dependent effects on survival and immune infiltration.

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.

The Legionella collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans

This study determines the crystal structure of Legionella collagen-like protein and reveals its unique binding mechanism for sulphated glycosaminoglycans.

Understanding the heterogeneity of alloreactive natural killer cell function inkidney transplantation

This study identifies NK cell subpopulations and their functional responses in kidney transplant patients, linking pre-transplant NK cell characteristics to long-term graft function.

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature.

The study shows that a delayed vaccine boost at day 100 post-prime enhances CD8 T cell memory response compared to day 30, with a distinct molecular signature in splenic cells.

Intranasal delivery of lipid nanoparticle encapsulated SARS-CoV-2 and RSV-targeting siRNAs reduces lung infection

This paper develops an intranasal lipid nanoparticle (LNP) delivery system for siRNAs targeting SARS-CoV-2 and RSV, showing effective reduction of lung infection in mice.

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer

This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

The paper shows that short anti-senescence interventions reduce radiation-induced frailty and premature ageing in mice, improving muscle, liver function, and memory.

Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine

A single dose of a SARS-CoV-2 spike vaccine delivered via a high-density microarray patch provides complete protection against a lethal virus challenge.

Oncogenic RAS activity predicts response to chemotherapy and outcome in lung adenocarcinoma

This study develops a transcriptional signature to measure RAS pathway activity in lung adenocarcinoma, showing it better predicts chemotherapy response and prognosis than KRAS mutation status.

GDV1 C-terminal truncation of 39 amino acids disrupts sexual commitment in Plasmodium falciparum

This study identifies a C-terminal truncation mutation in GDV1 that disrupts sexual commitment in Plasmodium falciparum by destabilizing the protein, despite normal nuclear import and HP1 interaction.

Loss of mutant TP53 does not impair the sustained proliferation, survival ormetastasis of diverse cancer cells

This study shows that removing mutant TP53 does not affect cancer cell survival, proliferation, or metastasis, suggesting GOF effects are not universally required for malignant growth.

Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.

Endogenous sugar level is associated with differential heat tolerance in onion bulb scales

This study shows that soluble sugars in onion bulb scales affect heat tolerance, with inner scales using sugars for osmoprotection and outer scales metabolizing them for skin formation.

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer

The paper describes a modified Helios mass cytometer protocol that improves data quality and reduces inter-instrument variability in multi-center studies.

A strategy to study intrinsically mixed folded proteins: The structure in solution of ataxin-3

This paper describes a strategy to assign the NMR spectrum of ataxin-3, revealing structural features of its disordered C-terminal tail and polyglutamine repeats.