J. Engelstaedter

Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ

The paper shows that optimal antimicrobial dosing combinations depend on the relative mutation rates of drugs, with a linear relationship in log-log space between dose ratios and mutation rate ratios.

The distribution of fitness effects during adaptive walks using a simple genetic network

This study models adaptation using a genetic network and finds that fitness effect distributions differ from theoretical expectations, showing fewer large-effect beneficial mutations and a bimodal distribution in the network model.

Host phylogeny and ecological associations best explain Wolbachia host shifts in scale insects

This study investigates Wolbachia host shifts in scale insects, finding that host phylogeny strongly influences strain sharing, while geography does not, and ecological associations facilitate host shifts.

Wolbachia in scale insects: a distinct pattern of infection frequencies and potential transfer routes via ant associates

The paper analyzes Wolbachia infection patterns in scale insects and identifies a correlation with ant associates, suggesting horizontal transfer routes.

Genetic slippage after sex maintains diversity for parasite resistance in a natural host population

The paper shows that genetic slippage after sex in Daphnia magna maintains resistance diversity despite strong selection against parasites.

A two-locus system with strong epistasis underlies rapid parasite-mediated evolution of host resistance

The paper identifies a two-locus epistatic system driving rapid host resistance evolution in response to a bacterial parasite.

Evolutionary epidemiology of Streptococcus iniae: linking mutation rate dynamics with adaptation to novel immunological landscapes

This study links mutation rate dynamics with adaptation in Streptococcus iniae, showing conserved mutation rates and MMR/OG genotypes within clades but variation between lineages associated with virulence and host adaptation.

Highly replicated evolution of parapatric ecotypes

This study shows that selection can repeatedly create similar ecotypes despite low gene flow between parapatric populations of Senecio lautus.

Phenotypic and genotypic parallel evolution in parapatric ecotypes of Senecio

This study examines phenotypic and genotypic parallel evolution in parapatric ecotypes of Senecio lautus, finding similar traits evolved through different genetic changes.

The dynamics of preferential host switching: host phylogeny as a key predictor of parasite prevalence and distribution

The paper develops a mathematical model to show how host phylogeny influences parasite prevalence and distribution through preferential host switching.