Y.-P. Lin

How weedy Arabidopsis thaliana dominated the world: ancestral variation and polygenic adaptation

This study identifies genetic factors underlying demographic turnover in Arabidopsis thaliana, showing polygenic adaptation contributes to the dominance of non-relict populations.

Scrutinizing science to save lives: uncovering flaws in the data linking L-type calcium channels blockers to CRAC channels and heart failure.

This paper critiques a study linking L-type calcium channel blockers to heart failure, identifying flaws in methodology, data interpretation, and mathematical analysis.

Environment as a limiting factor of the historical global spread of mungbean

This study investigates the historical spread of mungbean by analyzing genomes and environmental factors, finding that climatic adaptation, not just human activity, shaped its cultivation range expansion.

The structure of a hibernating ribosome in a Lyme disease pathogen

This study determines the structure of the hibernating ribosome in Borrelia burgdorferi using cryo-EM, revealing new structural features and insights into antibiotic binding.

Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism

This paper identifies a minor sequence variation in the CspZ protein of Borrelia burgdorferi that influences host-specific complement evasion and infectivity through FH-binding interface differences.

Distinct selection signatures during domestication and improvement in crops: a tale of two genes in mungbean

This study compares selection signatures in mungbean domestication and improvement, identifying distinct genomic footprints associated with different genes and selective pressures.

Co-infection of Ehrlichia with B. burgdorferi drives emergency myelopoiesis and promotes Lyme arthritis

This study shows that co-infection with Ehrlichia and Borrelia burgdorferi in mice causes arthritis and emergency myelopoiesis, highlighting immune signals over pathogen burden in disease development.

Phylogenomic diversity elucidates mechanistic insights into Lyme borreliae host association

This study investigates how genetic variation in Lyme disease-causing Borrelia burgdorferi strains relates to their ability to evade host complement immune responses, revealing host-specific complement-evasion phenotypes.

CspZ FH-binding sites as epitopes promote antibody-mediated Lyme borreliae clearance

The paper shows that antibodies targeting CspZ FH-binding sites effectively clear Lyme borreliae in vitro and in vivo, highlighting their importance for vaccine development.

Host adaptation drives genetic diversity in a vector-borne disease system

The paper investigates genetic diversity in Borrelia burgdorferi across different hosts and finds that genotype-specific host adaptation contributes to maintaining intraspecific diversity and influences disease risk.

Wolbachia in scale insects: a distinct pattern of infection frequencies and potential transfer routes via ant associates

The paper analyzes Wolbachia infection patterns in scale insects and identifies a correlation with ant associates, suggesting horizontal transfer routes.

Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

The paper identifies CspA as a determinant of host tropism in Lyme disease bacteria, showing convergent evolution drives transmission differences among vertebrates.

Host specialization in microparasites transmitted by generalist vectors: insights into the cellular and immunological mechanisms

This study investigates host specialization in Lyme disease bacteria by testing different genotypes in reservoir hosts, finding that bacterial persistence depends on adhesion and immune evasion traits.

Divergence in Thermostability of Arabidopsis Mitochondrial Nucleotide Exchange Factors Encoded by Duplicate Genes, MGE1 and MGE2

This study compares the thermostability of Arabidopsis MGE1 and MGE2, showing MGE2 is more stable and contributes to heat stress tolerance.