DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery
N. J. Kapolka, G. J. Taghon, J. B. Rowe, W. M. Morgan, J. F. Enten, D. G. Isom
DCyFIR enables high-throughput CRISPR-based profiling of GPCRs and ligand discovery by integrating receptors into yeast genomes and analyzing ligand specificity across multiple strains.
bioRxiv · Jan 16, 2020Pharmacology & Toxicology