J. F. Fay

Cryo-EM visualization of an active high open probability CFTR ion channel

The paper determines the structure of active and inactive states of a thermostabilized CFTR channel using cryo-EM, revealing structural changes related to channel function.

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

The paper presents a cryo-EM structure of the KATP channel, revealing assembly and gating mechanisms involving SUR1 and Kir6.2 interactions with ATP and PIP2.