Author

J. Z. Chen

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Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Evolutionary Biology· 2 Physiology· 2 Microbiology· 1 Pathology· 1

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Approach:experimental assay· 8 Assay:proteomics· 5 Approach:deep learning· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:protein folding & dynamics· 3 Research Focus:protein structure prediction· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

N. Tokuriki· 4 shared A. Daugherty· 3 shared D. A. Howatt· 2 shared D. M. Fowler· 2 shared H. S. Lu· 2 shared H. Sawada· 2 shared J. F. Fay· 2 shared J. J. Moorleghen· 2 shared

Activity by Year

2016-2024 · peak 3/yr

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10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

N. Tokuriki

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Author profile →

12 papers

Recent·Most cited

A strong priority effect in the assembly of a specialized insect-microbe symbiosis

J. Z. Chen, A. Junker, I. Zheng, N. M. Gerardo, N. M. Vega

The paper shows that the order of bacterial colonization in squash bugs strongly affects symbiont population establishment, regardless of strain competition or availability.

Applied and Environmental Microbiology · Oct 23, 2024Peer-reviewedMicrobiology

Understanding epistatic networks in the B1 -lactamases through coevolutionary statistical modeling and deep mutational scanning

J. Z. Chen, M. Bisardi, D. Lee, S. Cotogno, F. Zamponi, M. Weigt, N. Tokuriki

The paper uses coevolutionary analysis and deep mutational scanning to study epistatic networks in B1-lactamases, revealing both conserved and specific interactions across homologs.

bioRxiv · Nov 27, 2023Biochemistry

Structural insights into the heterotrimeric alternatively spliced P2X7 receptorsCondensed title: Structures of heterotrimeric P2X7 receptors

S. K. F. De Salis, J. Z. Chen, K. K. Skarratt, S. J. Fuller, T. Balle

This study uses AlphaFold2-Multimer to generate structures of heterotrimeric P2X7 receptors, revealing structural insights and potential functional differences in splice variants.

bioRxiv · May 30, 2023 · PreprintBiophysics

Neutral Drift and Threshold Selection Promote Phenotypic Variation

A. N. Erdogan, P. Dasmeh, R. D. Socha, J. Z. Chen, B. E. Life, R. Jun, L. Kiritchkov, D. Kehila, A. W. R. Serohijos, N. Tokuriki

The paper shows neutral drift and threshold selection generate phenotypic variation in antibiotic resistance genes without adaptation.

bioRxiv · Apr 5, 2023Evolutionary Biology

Environmental selection and epistasis in an empirical phenotype-environment-fitness landscape

J. Z. Chen, D. M. Fowler, N. Tokuriki

The paper constructs an empirical phenotype-fitness landscape for VIM-2 β-lactamase across ampicillin concentrations, showing environmental dependence of mutational effects and nonspecific epistasis.

bioRxiv · Apr 14, 2021Evolutionary Biology

Losartan Increases Survival of the Fbn1mgR/mgR Mouse Model of Marfan Syndrome in and Age-Dependent Manner

J. D. Smith, J. Z. Chen, R. Phillip, A. Daugherty, M. B. Sheppard

This study shows that losartan improves survival in male Fbn1mgR/mgR mice when started at 50 days old but not at 24 days, while no benefit was seen in females.

bioRxiv · Feb 19, 2021 · PreprintPhysiology

Inhibition of Angiotensin II Dependent AT1a Receptor Stimulation Attenuates Thoracic Aortic Pathology in Fibrillin-1C1041G/+ Mice

J. Z. Chen, H. Sawada, J. J. Moorleghen, M. K. Franklin, D. A. Howatt, M. B. Sheppard, A. E. Mullick, H. S. Lu, A. Daugherty

This study shows that inhibiting the AngII-AT1aR axis reduces aortic pathology in male Fbn1C1041G/+ mice, suggesting ligand-dependent AT1aR stimulation contributes to TAA progression.

bioRxiv · Jun 1, 2020Physiology

Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase.

J. Z. Chen, D. M. Fowler, N. Tokuriki

This study uses deep mutational scanning to analyze VIM-2 lactamase variants, identifying residues affecting stability, translocation, and substrate specificity across different temperatures.

bioRxiv · Feb 19, 2020Biochemistry

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies

H. Sawada, Y. Katsumata, H. Higashi, C. Zhang, Y. Li, S. Morgan, L. H. Lee, S. A. Singh, J. Z. Chen, D. A. Howatt, J. J. Moorleghen, M. K. Franklin, D. L. Rateri, Y. H. Shen, S. A. LeMaire, , A. Daugherty

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

bioRxiv · Feb 2, 2020Pathology

Convergent Allostery in Ribonucleotide Reductase

W. C. Thomas, F. P. Brooks, A. A. Burnim, J.-P. Bacik, J. Stubbe, J. T. Kaelber, J. Z. Chen, N. Ando

This study identifies a new allostery mechanism in Bacillus subtilis RNR through structural analysis, revealing convergent regulation of enzyme activity.

bioRxiv · Dec 21, 2018Biochemistry

Cryo-EM visualization of an active high open probability CFTR ion channel

J. F. Fay, L. A. Aleksandrov, T. J. Jensen, L. L. Cui, J. N. Kousouros, L. He, A. A. Aleksandrov, D. S. Gingerich, J. Riordan, J. Z. Chen

The paper determines the structure of active and inactive states of a thermostabilized CFTR channel using cryo-EM, revealing structural changes related to channel function.

bioRxiv · Mar 2, 2018Biophysics

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

G. M. Martin, C. Yoshioka, E. A. Rex, J. F. Fay, Q. Xie, M. R. Whorton, J. Z. Chen, S.-L. Shyng

The paper presents a cryo-EM structure of the KATP channel, revealing assembly and gating mechanisms involving SUR1 and Kir6.2 interactions with ATP and PIP2.

bioRxiv · Dec 16, 2016Biochemistry