Q. Xie

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

Multi-omic Analysis Identifies Glioblastoma Dependency on H3K9me3 Methyltransferase Activity

This study identifies H3K9me3 methyltransferases as key drivers in glioblastoma, showing their association with prognosis, immune response, and drug response through multi-omics analysis.

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

This study examines how antiretroviral treatment affects immune responses in the brain and blood of EcoHIV-infected mice, identifying treatment-induced changes in cytokine and chemokine expression.

Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

A Day in the Life of Arabidopsis: 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms

This study uses snRNA-seq to analyze circadian rhythms in Arabidopsis over 24 hours, revealing cell-type specific gene expression patterns and identifying key circadian regulators.

Duhuo Jisheng Decoction Regulates Intracellular Zinc Homeostasis by Enhancing Autophagy via PTEN/Akt/mTOR to Improve Knee Cartilage Degeneration

This study investigates how Duhuo Jisheng Decoction protects cartilage by enhancing autophagy through the PTEN/Akt/mTOR pathway and regulating zinc homeostasis.

Rapid and unbiased enrichment of extracellular vesicles via meticulously engineered peptide

This paper introduces a method to rapidly and efficiently isolate extracellular vesicles with high purity and recovery, enabling downstream analyses for cancer diagnostics.

Complex epistatic interactions between ELF3, PRR9, and PRR7 regulates the circadian clock and plant physiology

The paper investigates the genetic interactions between ELF3, PRR9, and PRR7 in Arabidopsis, revealing complex epistatic relationships affecting circadian rhythms and plant development.

Structural insights into dual-antagonize mechanism of AB928 on adenosine A2 receptors

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

Semi-rational evolution of a recombinant DNA polymerase for modified nucleotide incorporation efficiency

This study improves a DNA polymerase's ability to incorporate modified nucleotides through combinatorial mutagenesis, resulting in a 20-fold efficiency gain.

Crystal structure of a mammalian CMTM6 and its interaction model with PD-L1

The paper reports the first experimentally determined structure of CMTM6 and proposes an interaction model with PD-L1, providing structural insights into its role in stabilizing the PD-1/PD-L1 axis.

Wounding promotes root regeneration through a cell wall integrity sensor, the receptor kinase FERONIA

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn2+-releasing mechanism

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

Rational evolution of a recombinant DNA polymerase for efficient incorporation of unnatural nucleotides by dual-site boosting

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis

This study identifies MroQ as the second protease in the S. aureus agr quorum sensing pathway, showing its role in AIP biosynthesis and revealing molecular features guiding its cleavage activity.

Single-cell Stereo-seq enables cell type-specific spatial transcriptome characterization in Arabidopsis leaves

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

CAR modulates plasma membrane nano-organization and immune signaling downstream of RALF1-FERONIA signaling pathway

This study shows that the FER-CAR module regulates plasma membrane nano-organization and immune signaling through a feedback loop during RALF1 signaling.

Engineered AIM-based Selective Autophagy to Degrade Proteins and Organelles

The paper introduces a method to degrade specific proteins and organelles using engineered autophagy receptors, demonstrating its effectiveness in plant and transient expression systems.

Endogenous RNA editing of a nuclear gene BOSS triggers flowering in tomato

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana

This study identifies SLIM1 as a transcription factor essential for arsenic resistance in Arabidopsis thaliana, showing its role in reducing oxidative stress and enhancing thiol/sulfate accumulation.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

Development and Application of Cas13a-based Diagnostic Assay for Neisseria Gonorrhoeae Detection and Identification of Azithromycin Resistance

This paper develops a Cas13a-based assay for detecting Neisseria gonorrhoeae and identifying azithromycin resistance mutations, showing high sensitivity and concordance with existing methods.

An amiRNA screen uncovers redundant CBF & ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses

Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions

This paper develops a 3D reconstruction method using ATUM-SEM and deep learning to analyze hepatic organelle interactions and their morphology.

Phytophthora sojae effector Avr1d functions as E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

Targeting KRAS-mutant stomach/colorectal tumours by disrupting the ERK2-p53 complex

This study identifies the ERK2-p53 complex as a therapeutic target in KRAS-mutant stomach/colorectal cancers, showing that disrupting it with MEK1/2 and ERK2 inhibitors induces apoptosis.

Seasonal Variation in the Internet Searches for Cancer Recurrence: An Infodemiological Study

This study uses internet search data to show seasonal variation in cancer recurrence queries, with peaks in early summer (northern hemisphere) and late summer (southern hemisphere).

Hemimetabolous genomes reveal molecular basis of termite eusociality

The paper compares genomes and transcriptomes of termites and cockroaches to identify molecular mechanisms underlying termite eusociality, finding parallels and differences with Hymenoptera.

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

The paper presents a cryo-EM structure of the KATP channel, revealing assembly and gating mechanisms involving SUR1 and Kir6.2 interactions with ATP and PIP2.