C24 sphingolipids play a surprising and central role in governing cholesterol and lateral organization of the live cell plasma membrane
K. C. Courtney, W. Pezeshkian, R. Raghupathy, G. Zhang, A. Darbyson, J. H. Ipsen, D. A. Ford, H. Khandelia, J. F. Presley, X. Zha
This study shows that C24 sphingomyelin in the outer leaflet suppresses membrane microdomains by directing cholesterol to the inner leaflet, while C16 sphingomyelin promotes microdomains.
bioRxiv · Oct 31, 2017Cell Biology