Author

X. Zha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Sorisky· 2 shared J. Dilworth· 2 shared J. McDonald· 2 shared K. Dauner· 2 shared K. Nakka· 2 shared N. Verma· 2 shared A. Darbyson· 1 shared B.-L. Song· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

A. Sorisky

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Phosphodiesterase-5 inhibition inhibits epithelial ATP release and restores detrusor contractility in rats with type 2 diabetes via an increase in bladder blood flow

T. Kabuto, S. Inamura, H. Kobayashi, X. Zha, K. Nagase, M. Taga, M. Seki, N. Tanaka, Y. Okumura, O. Yokoyama, N. Terada

This study shows that PDE-5 inhibition improves bladder function in T2DM rats by increasing blood flow, reducing ATP release, and modulating inflammatory and growth factor markers.

bioRxiv · Mar 26, 2024 · PreprintPharmacology & Toxicology

Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3

Z. Saiioum, K. Dauner, Y.-f. Li, N. Verma, V. Almendro-Vedia, D. VALDIVIESO GONZALEZ, D. J. Zhang, K. Nakka, J. McDonald, A. Sorisky, B.-L. Song, I. Lopez Montero, J. Luo, J. Dilworth, X. Zha

This study shows statins reduce macrophage cholesterol, upregulate JMJD3, and shift macrophage activation toward anti-inflammatory responses in both M1 and M2 states.

bioRxiv · Jan 9, 2023Biochemistry

Reducing Cholesterol in Resting Macrophage Activates NF-kB through Mitochondria, Resulting in Epigenomic Reprogramming to Dampen Inflammation in Activated Macrophages

X. Zha, Z. Salloum, K. Dauner, K. Nakka, N. Verma, H. Bandukwala, A. Sorisky, J. Dilworth, D. V. Gonzalez, V. A. Vedia, I. Lopez-Montero, J. McDonald, C. D. Corley

bioRxiv · Feb 10, 2022 · PreprintCell Biology

High-glucose Induces Retinal Pigment Epithelium Mitochondrial Pathways of Apoptosis and Inhibits Mitophagy by Regulating ROS/PINK1/Parkin Signal Pathway

Y. Yang, X. Zha, Y. Zhang, X. Xi, Y. Mei, X. Zhao, L. Zhou, M. Ma, S. Liu

This study shows high-glucose induces RPE apoptosis and inhibits mitophagy by disrupting the ROS/PINK1/Parkin pathway.

bioRxiv · Sep 18, 2018Cell Biology

C24 sphingolipids play a surprising and central role in governing cholesterol and lateral organization of the live cell plasma membrane

K. C. Courtney, W. Pezeshkian, R. Raghupathy, G. Zhang, A. Darbyson, J. H. Ipsen, D. A. Ford, H. Khandelia, J. F. Presley, X. Zha

This study shows that C24 sphingomyelin in the outer leaflet suppresses membrane microdomains by directing cholesterol to the inner leaflet, while C16 sphingomyelin promotes microdomains.

bioRxiv · Oct 31, 2017Cell Biology