Author

H. Khandelia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Approach:statistical model· 3 Approach:biophysical modeling· 2 Organism:human· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

V. Dubey· 3 shared B. P. Pedersen· 2 shared D. L. Stokes· 2 shared W. Pezeshkian· 2 shared A. A. Hakami Zanjani· 1 shared A. Darbyson· 1 shared A. Kamp-Sonne· 1 shared B. Bozorg· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiophysics

V. Dubey

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Phospholamban Inhibits the Cardiac Calcium Pump Through Reversing the Allosteric Enhancement of Calcium Affinity by ATP

S. R. Cleary, J. Seflova, E. E. Cho, K. Bisht, H. Khandelia, L. M. Espinoza-Fonseca, S. L. Robia

This paper investigates how phospholamban (PLB) inhibits the cardiac calcium pump SERCA by reversing ATP-induced allosteric enhancement of calcium affinity, using biochemical assays and structural analysis.

bioRxiv · Jul 20, 2023 · PreprintBiochemistry

The ATP-bound State of the Uncoupling Protein 1 (UCP1) from Molecular Simulations

L. Jacobsen, L. Lydersen, H. Khandelia

This study uses molecular dynamics simulations to generate the ATP-bound conformation of UCP1 and proposes mechanisms for ATP-mediated inhibition of proton leak.

bioRxiv · Mar 17, 2023Biophysics

An intracellular pathway controlled by the N-terminus of the pump subunit inhibits the bacterial KdpFABC ion pump in high K+ conditions

H. Khandelia, D. L. Stokes, B. P. Pedersen, V. Dubey

This study uses molecular dynamics simulations to show phosphorylation of KdpB traps it in an inactive conformation by hydrating the ion-binding site via an intracellular pathway.

bioRxiv · Jan 13, 2021Biophysics

Annexin A4 trimers are recruited by high membrane curvatures in Giant Plasma Membrane Vesicles

C. D. Florentsen, A. Kamp-Sonne, G. M. Pescador, W. Pezeshkian, A. A. Hakami Zanjani, H. Khandelia, J. Nylandsted, P. M. Bendix

This study investigates how ANXA4 trimers sense and respond to membrane curvature in GPMVs, revealing their role in membrane repair and curvature sensing.

bioRxiv · Feb 20, 2020Biophysics

Serine Phosphorylation Regulates the P-type Potassium pump KdpFABC

M. E. Sweet, V. L. Dubey, X. Zhang, H. Erdjument-Bromage, T. A. Neubert, B. P. Pedersen, H. Khandelia, D. L. Stokes

The paper shows that serine phosphorylation of KdpB inhibits the KdpFABC potassium pump when K+ levels are restored, with mutations affecting pump activity.

bioRxiv · Jan 28, 2020Biophysics

Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain

V. Dubey, B. Bozorg, D. Wuestner, H. Khandelia

This study shows that cholesterol binding to the SSD of NPC1 restricts NTD dynamics, suggesting an allosteric feedback mechanism regulating lysosomal cholesterol levels.

bioRxiv · Nov 25, 2019Biophysics

A single K+-binding site in the crystal structure of the gastric proton pump

K. Yamamoto, V. Dubey, K. Irie, H. Nakanishi, H. Khandelia, Y. Fujiyoshi, K. Abe

The paper determines the crystal structure of the gastric proton pump, revealing a single K+-binding site and confirming a 1H+/1K+ exchange per ATP hydrolysis.

bioRxiv · Apr 15, 2019Biochemistry

On identifying collective displacements in apo-proteins that reveal eventual binding pathways

D. D. Prakashchand, N. Ahalawat, H. Khandelia, J. Mondal, S. Sengupta

The paper identifies collective displacements in apo-proteins that correlate with binding pathways without requiring actual binding events.

bioRxiv · Jun 8, 2018Biophysics

C24 sphingolipids play a surprising and central role in governing cholesterol and lateral organization of the live cell plasma membrane

K. C. Courtney, W. Pezeshkian, R. Raghupathy, G. Zhang, A. Darbyson, J. H. Ipsen, D. A. Ford, H. Khandelia, J. F. Presley, X. Zha

This study shows that C24 sphingomyelin in the outer leaflet suppresses membrane microdomains by directing cholesterol to the inner leaflet, while C16 sphingomyelin promotes microdomains.

bioRxiv · Oct 31, 2017Cell Biology