P1 bacteriophage-enabled delivery of CRISPR-Cas9 antimicrobial activity against Shigella flexneri
Y. W. Huan, V. Torraca, R. Brown, J. Fa-arun, S. L. Miles, D. A. Oyarzun, S. Mostowy, B. Wang
This study uses a P1 bacteriophage to deliver CRISPR-Cas9 for targeted killing of Shigella flexneri in zebrafish larvae, reducing bacterial load and improving survival.
bioRxiv · Sep 2, 2022Microbiology