S. Mostowy

High-content high-resolution microscopy and deep learning assisted analysis reveals host and bacterial heterogeneity during Shigella infection

The paper uses high-resolution microscopy and deep learning to analyze host and bacterial heterogeneity during Shigella infection, revealing SEPT7 recruitment patterns linked to T3SS activation.

Septins and K63 chains form separate bacterial microdomains during autophagy of entrapped Shigella

The paper investigates how septins and K63 ubiquitin chains form separate microdomains during autophagy of Shigella, revealing their distinct recruitment during antibacterial defense.

Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish

This paper shows that three Shigella serotypes associated with MSM transmission can establish persistent infection in zebrafish, failing to promote macrophage cell death.

Shigella induces epigenetic reprogramming of zebrafish neutrophils

This study shows Shigella primes zebrafish neutrophils to enhance bacterial clearance through epigenetic changes and mitochondrial ROS, distinct from BCG or β-glucan training.

Acquisition of a large virulence plasmid (pINV) promoted temperature-dependent virulence and global dispersal of O96:H19 enteroinvasive Escherichia coli

The paper shows that acquisition of the pINV plasmid in ST99 E. coli made its virulence temperature-dependent, aiding global dispersal.

Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri

This study uses zebrafish to identify host factors, like gpr84, that influence susceptibility to Shigella flexneri infection through transcriptional profiling.

An automated microscopy workflow to study Shigella-neutrophil interactions and antibiotic efficacy in vivo

The paper develops an automated microscopy workflow to study Shigella-neutrophil interactions and antibiotic efficacy in zebrafish, revealing that nalidixic acid restricts Shigella dissemination.

P1 bacteriophage-enabled delivery of CRISPR-Cas9 antimicrobial activity against Shigella flexneri

This study uses a P1 bacteriophage to deliver CRISPR-Cas9 for targeted killing of Shigella flexneri in zebrafish larvae, reducing bacterial load and improving survival.

A membrane-depolarising toxin substrate of the Staphylococcus aureus Type VII secretion system mediates intra-species competition

This paper identifies TspA as a new T7SS substrate in S. aureus, showing it mediates intra-species competition by membrane depolarization and growth inhibition in vivo.

Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence

This paper shows that Shigella sonnei's O-antigen mediates neutrophil tolerance and increases dysentery incidence in zebrafish, suggesting O-antigen as a therapeutic target.

In vivo control of Toxoplasma gondii by zebrafish macrophages

This study uses a zebrafish model to show that macrophages control Toxoplasma gondii infection in vivo, with type II and III strains having higher infectious burdens than type I.

Shigella sonnei O-antigen inhibits internalisation, vacuole escape and inflammasome activation

This study shows that S. sonnei's O-antigen reduces macrophage uptake and vacuole escape, leading to less pyroptosis compared to S. flexneri.