Author

J. Fric

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

V. Bosakova· 5 shared F. Kafka· 3 shared B. Verstockt· 2 shared B.-J. Ke· 2 shared F. Biscu· 2 shared G. Forte· 2 shared G. Matteoli· 2 shared I. Papatheodorou· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersImmunology

V. Bosakova

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

S. Morazzo, S. Fernandes, M. Fortea, H. Skalova, M. Cassani, K. Vrzalova, F. Kafka, J. Vrbsky, D. Pereira de Sousa, V. Bosakova, J. Shin, J. Fric, K. Haase, G. Forte

This study shows ERK3 promotes TNBC progression through EMT plasticity and collective migration, linking it to poor clinical outcomes.

bioRxiv · Jun 20, 2024Cancer Biology

Unveiling the guardians: IL-26-expressing MAIT cells protect epithelial barrier function and are dysregulated in Crohn's disease

V. Bosakova, B.-J. Ke, M. Hortova Kohoutkova, I. Papatheodorou, F. Kafka, M. D. Zuani, S. Santhosh, F. Biscu, S. Abdurahiman, I. D. Greef, S. Verstockt, B. Verstockt, S. Vermeire, R. J. Arguello, G. Matteoli, J. Fric

This study identifies IL-26-expressing MAIT cells as protective for epithelial barrier function and shows their dysregulation in Crohn's disease.

bioRxiv · Jun 2, 2024 · PreprintImmunology

Serotonin attenuates tumor-necrosis-factor-alpha-induced intestinal inflammation by interacting with human mucosal tissue

V. Bosakova, I. Papatheodorou, Z. Tomasikova, F. Kafka, M. Hortova Kohoutkova, J. Fric

This study shows serotonin reduces inflammation in intestinal tissue by altering monocyte behavior and chemokine expression using a human 3D model.

bioRxiv · May 5, 2024Immunology

Intercellular interaction between FAP fibroblasts and CD150 inflammatory monocytes mediates fibro-stenosis in Crohn's disease

B.-J. Ke, S. Abdurahiman, F. Biscu, G. Dragoni, S. Santhosh, V. De Simone, A. Zouzaf, L. van Baarle, M. Stakenborg, V. Bosakova, Y. Van Rymenant, E. Verhulst, S. Verstockt, G. Bislenghi, A. Wolthuis, , G. Matteoli

The paper identifies intercellular interactions between FAP fibroblasts and CD150 monocytes that drive fibro-stenosis in Crohn's disease and shows TWIST1 inhibition can reduce fibrosis.

bioRxiv · May 4, 2023Immunology

TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

S. Fernandes, J. Oliver-De La Cruz, M. Cassani, S. Morazzo, H. Durikova, A. Caravella, P. Fiore, G. Azzato, G. De Marco, A. Lauria, V. Izzi, V. Bosakova, J. Fric, P. Filipensky, G. Forte

This study shows TGF-β signaling drives ECM changes and EMT in prostate cancer tumoroids, promoting tumor progression.

bioRxiv · Apr 3, 2023Cancer Biology