M. Cassani

An iPSC-derived bio-inspired scaffold modelling the structure and the effects of extracellular matrix in cardiac fibrosis

This paper develops a bio-inspired scaffold from iPSC-derived cardiac myofibroblasts to model fibrotic ECM effects on cardiomyocytes.

Cooperative dynamics of DNA grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami

This study shows that DNA grafting density on magnetic nanoparticles affects their dynamics and biosensing performance, with optimal sensitivity at intermediate densities.

TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

This study shows TGF-β signaling drives ECM changes and EMT in prostate cancer tumoroids, promoting tumor progression.

YAP signaling regulates the cellular uptake and therapeutic effect of nanoparticles

This study shows that inhibiting YAP enhances nanoparticle uptake in triple-negative breast cancer cells, suggesting YAP targeting could improve nanotherapy effectiveness.

Generation and Maturation of Human iPSC-derived Cardiac Organoids in Long Term Culture

This study develops a scaffold-free protocol to generate long-term beating human cardiac organoids from hiPSCs, showing improved maturation and functionality for drug testing and cardiotoxicity studies.

Puromycin reactivity does not accurately localize translation at the subcellular level

The paper shows that puromycin-labeled peptides can diffuse away from ribosomes even with elongation inhibitors, leading to misleading subcellular localization of translation.