Author

R. J. Arguello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 5 Organism:human· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. J. Combes· 3 shared B. Samad· 3 shared J. Tsui· 3 shared M. F. Krummel· 3 shared A. A. Rao· 2 shared A. Boissonnas· 2 shared K. C. Barry· 2 shared P. Yan· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

A. J. Combes

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Metabolically Primed Multipotent Hematopoietic Progenitors Fuel Innate Immunity

J. Cosgrove, A.-M. Lyne, I. Rodriguez, V. Cabeli, S. Tenreira-Bento, E. Tubeuf, E. Russo, F. Tabarin, Y. Belloucif, S. Maleki-Toyserkani, S. Reed, F. Monaco, A. Ager, C. Lobry, P. Bousso, , L. Perie

The paper identifies metabolic cues that guide innate immune cell development by showing how HSPC metabolism influences myeloid differentiation and immune cell production.

bioRxiv · Jan 24, 2023 · PreprintImmunology

Light-inducible T cell engagers trigger, tune and shape the activation of primary T cells

M. Jaeger, A. Anastasio, S. Brustlein, R. Vincentelli, F. Durbesson, R. Char, M. Boussand, M. Lechelon, R. J. Arguello, D. Marguet, H.-T. He, R. Lasserre

The paper introduces a light-inducible T cell engager system to study how temporal TCR stimulation patterns influence T cell activation and cytokine responses.

bioRxiv · Apr 15, 2022 · PreprintImmunology

CARD9 in Neutrophils Protects from Colitis and Controls Mitochondrial Metabolism and Cell Survival

C. Danne, C. Michaudel, J. Skerniskyte, J. Planchais, A. Magniez, A. Agus, M.-L. Michel, B. Lamas, G. Da-Costa, M. Spatz, C. Oeuvray, C. Galbert, M. Poirier, Y. Wang, A. Lapiere, , H. Sokol

This study identifies CARD9's protective role in neutrophils against colitis by maintaining mitochondrial function and cell survival, revealing a mechanism for intestinal inflammation control.

bioRxiv · Jan 14, 2022Immunology

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

H. Hong, N. Mbah, M. Shan, K. Loesel, L. Lin, P. Sajjakulnukit, A. Andren, A. Hayashi, B. Magnuson, Z. Li, Y. Xie, L. Zhang, Y. L. Lei, A. Opipari, R. J. Arguello, , C. A. Lyssiotis

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

bioRxiv · Oct 1, 2021 · PreprintImmunology

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

A. M. Mujal, A. J. Combes, A. A. Rao, M. Binnewies, B. Samad, J. Tsui, A. Boissonnas, J. L. Pollack, R. J. Arguello, M. K. Ruhland, K. C. Barry, V. Chan, M. F. Krummel

This study characterizes monocyte-to-macrophage differentiation in kidney cancer using scRNA-seq, linking immune phenotypes to T cell function and patient outcomes.

bioRxiv · Jul 7, 2021Immunology

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

A. J. Combes, B. Samad, J. Tsui, N. W. Chew, P. Yan, G. C. Reeder, D. Kushnoor, A. Shen, B. Davidson, A. J. Barczac, M. Adkisson, A. Edwards, M. Naser, K. C. Barry, T. Courau, , M. F. Krummel

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

bioRxiv · Apr 26, 2021 · PreprintImmunology

Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection

D. Hudrisier, D. Corral, A. Charton, M. Z. Krauss, E. Blanquart, F. Levillain, E. Lefrancais, T. Sneperger, J.-P. Girard, G. Eberl, Y. Poquet, J.-C. Guery, R. J. Arguello, M. R. Hepworth, O. Neyrolles

This study shows that Mycobacterium tuberculosis infection drives immature lung ILC2 to differentiate into ILC1-like cells through type 1 cytokines and a glycolytic program controlled by HIF1.

bioRxiv · Jan 19, 2021Immunology

SCENITH: A flow cytometry based method to functionally profile energy metabolism with single cell resolution

R. J. ARGUELLO, A. J. COMBES, R. CHAR, E. BOUSIQUOT, J. P. GIGAN, V. CAMOSSETO, B. SAMAD, J. TSUI, P. YAN, S. BOISSONNEAU, D. FIGARELLA-BRANGER, E. GATTI, E. TABOURET, M. F. Krummel, P. PIERRE

SCENITH functionally profiles energy metabolism at single-cell resolution using flow cytometry, revealing variable metabolic profiles in tumor myeloid cells not linked to lineage or activation phenotype.

bioRxiv · Mar 10, 2020Immunology