Author

J. G. Heddle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

R. D. Suessmuth· 2 shared W. Czyszczon· 2 shared B. Kuropka· 1 shared B. Loll· 1 shared D. A. Ghilarov· 1 shared D. Ghilarov· 1 shared E. Michalczyk· 1 shared E. Pyza· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

R. D. Suessmuth

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Author profile →

3 papers

Recent·Most cited

Reengineering of an artificial protein cage for efficient packaging of active enzymes

Y. Azuma, S. Gaweł, M. Pasternak, O. Woznicka, E. Pyza, J. G. Heddle

This paper describes an artificial protein cage system that efficiently packages active enzymes while maintaining their catalytic activity through a post-assembly loading approach.

bioRxiv · Dec 8, 2023Bioengineering

Gene amplifications cause high-level resistance against albicidin in Gram-negative bacteria

M. Saathoff, S. Kosol, T. Semmler, S. A. Wolf, N. Dimos, J. Kupke, M. Seidel, F. Ghaziasaeedi, K. Tedin, B. Kuropka, W. Czyszczon, D. Ghilarov, S. Graetz, J. G. Heddle, B. Loll, , M. Fulde

This study identifies gene amplification as a mechanism conferring high-level resistance to albicidin in Gram-negative bacteria, validated across multiple species.

bioRxiv · Sep 15, 2022Microbiology

Pentapeptide repeat proteins QnrB1 and AlbG require ATP hydrolysis to rejuvenate poisoned gyrase complexes

L. Mazurek, D. A. Ghilarov, E. Michalczyk, Z. Pakosz, W. Czyszczon, K. Wawro, I. Behroz, R. D. Suessmuth, J. G. Heddle

This study investigates how QnrB1 and AlbG protect gyrase from poisons by requiring ATP hydrolysis, showing QnrB1 binds to GyrB and acts as a DNA mimic.

bioRxiv · Sep 24, 2020Biochemistry