Author

M. Saathoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. U. Ahmed· 3 shared C. Park· 3 shared C. Horbinski· 2 shared J. M. Shireman· 2 shared J. Miska· 2 shared S. Baisiwala· 2 shared A. K. Tryba· 1 shared A. Sonabend· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

A. U. Ahmed

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gene amplifications cause high-level resistance against albicidin in Gram-negative bacteria

M. Saathoff, S. Kosol, T. Semmler, S. A. Wolf, N. Dimos, J. Kupke, M. Seidel, F. Ghaziasaeedi, K. Tedin, B. Kuropka, W. Czyszczon, D. Ghilarov, S. Graetz, J. G. Heddle, B. Loll, , M. Fulde

This study identifies gene amplification as a mechanism conferring high-level resistance to albicidin in Gram-negative bacteria, validated across multiple species.

bioRxiv · Sep 15, 2022Microbiology

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

S. Baisiwala, S. Budhiraja, A. Zolp, K. Nandoliya, L. Chen, C. Park, E. Perrault, M. Saathoff, C. Dmello, J. Shireman, P. Lin, G. Dara, K. McCortney, C. Horbinski, A. Sonabend, A. U. Ahmed

The paper identifies PSMB3 as a contributor to gliomagenesis through proteasome-dependent and independent mechanisms using a CRISPR-Cas9 screen in GBM.

bioRxiv · Jul 28, 2021 · PreprintCancer Biology

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

J. M. Shireman, F. Atashi, G. Lee, E. Ali, M. Saathoff, C. Park, S. Baiswala, J. Miska, M. Lesniak, J. C. David, R. Stupp, P. Kumthekar, C. Horbinski, I. Ben-Sahar, A. U. Ahmed

This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.

Brain · Apr 14, 2021Peer-reviewedCancer Biology

Activation of dopamine receptor 2 (DRD2) prompts transcriptomic and metabolic plasticity in glioblastoma

S. P. Caragher, J. M. Shireman, M. Huang, J. Miska, S. Baisiwala, C. Park, M. Saathoff, L. Warnke, T. Xiao, M. S. Lesniak, C. D. James, H. Meltzer, A. K. Tryba, A. U. Ahmed

This paper shows that dopamine receptor 2 activation in glioblastoma cells increases their growth, stemness, and metabolic activity, suggesting dopamine signaling as a therapeutic target.

bioRxiv · Nov 16, 2018Cancer Biology