The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat
D. C. Montefiori, M. V. Filsinger Interrante, B. N. Bell, A. A. Rubio, J. G. Joyce, J. W. Shiver, C. C. LaBranche, P. S. Kim
This paper shows that the FcγRI receptor enhances HIV-1 neutralization by NHR-targeting antibodies, enabling neutralization of tier-2 viruses.
bioRxiv · Aug 27, 2020Immunology