Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein
L. Plate, B. Rius, B. Nguyen, J. Genereux, J. W. Kelly, R. L. Wiseman
The paper identifies how ATF6 activation reduces secretion of a destabilized amyloidogenic protein by enhancing its retention in the ER through specific proteostasis factors.
bioRxiv · Jul 31, 2018Cell Biology