B. Nguyen

AHR activation accelerates the resolution of TGF-β1 induced fibroblast activation and promotes alveolar type 1 cell regeneration in alveolar organoids

The paper identifies DB-11-BE87 as a compound that promotes AT1 cell regeneration by reducing TGF-β1-induced fibroblast activation through AHR activation in alveolar organoids.

WISH-BONE: Whole-mount In Situ Histology, to label osteocyte mRNA and protein in 3D adult mouse bones

WISH-BONE labels osteocyte mRNA and protein in 3D adult mouse bones, enabling spatially preserved biomarker expression analysis.

Subunit Communication within Dimeric SF1 DNA Helicases

This study shows that specific dimer interactions and ATPase activity in both subunits are required for helicase activity in E. coli Rep and UvrD, with subunit communication demonstrated through Trp fluorescence.

Mycobacterium tuberculosis Ku stimulates multi-round DNA unwinding by UvrD1 monomers

This study shows that Mtb Ku stimulates UvrD1 monomers to unwind DNA in multiple rounds, revealing a mechanism for DNA repair activation in mycobacteria.

RecA levels modulate biofilm development in Acinetobacter baumannii

This study shows that varying RecA levels in Acinetobacter baumannii affect biofilm formation and dispersal through the regulator bfmR, highlighting the role of DDR in infection persistence.

Disease-associated patterns of acetylation stabilize tau fibril formation

This study identifies acetylation patterns that drive tau fibril formation and shows their structural and functional role in tauopathies.

Helicase Activity Promoted Through Dynamic Interactions Between a ssDNA Translocase and a Diffusing SSB Protein

The paper shows that Pif1 helicase uses its translocase activity to push RPA along ssDNA, disrupting duplex DNA and demonstrating a new mechanism for directional DNA unwinding.

Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.

This study predicts microbiota responses to environmental pH and osmolality by analyzing bacterial growth under controlled conditions and identifying predictive genes and pathways.

Modifying the trajectory of epicardial leads can substantially reduce MRI-induced RF heating in pediatric patients with a cardiac implantable electronic device

This study shows that modifying epicardial lead trajectories can significantly reduce MRI-induced RF heating in pediatric patients with cardiac implants.

The impact of multigenerational high-fat diet feeding on the gut microbiome and host metabolism

This study shows that multigenerational high-fat diet feeding in mice leads to improved metabolic health through microbiome adaptation, with leaner mice passing on resistance to obesity.

How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

This study shows that potassium glutamate promotes liquid-liquid phase separation and non-nearest-neighbor cooperativity of E. coli SSB protein through amide group interactions, while KCl inhibits these processes.

Density-by-diet interactions during larval development shape adult life-history trait expression and fitness in a polyphagous fly

This study investigates how larval density and diet interact to influence adult life-history traits and fitness in Bactrocera tryoni, showing diet-specific effects on development, fecundity, and lipid reserves.

Yersinia pseudotuberculosis doxycycline tolerance strategies include modulating expression of genes involved in cell permeability and tRNA modifications

This study identifies gene expression changes in Yersinia pseudotuberculosis in response to doxycycline, showing that OmpF porin and TusB tRNA modification influence antibiotic tolerance.

Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

Mycobacterium tuberculosis DNA-repair helicase UvrD1 is activated by redox-dependent dimerization via a conserved 2B domain cysteine.

This study shows that Mtb UvrD1 dimerizes under oxidative conditions, enhancing its DNA unwinding activity through a conserved cysteine in the 2B domain.

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activation

This paper shows that HODHBt enhances NK cell effector and memory-like functions by boosting IL-15-mediated STAT activation, leading to increased cytotoxicity and cytokine secretion.

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

The paper analyzes genomic data from 25,000 patients to identify associations between genomic alterations and metastatic patterns across 50 tumor types, finding chromosomal instability correlates with metastatic burden in some cancers.

Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint

The paper shows that PRC2/PRC1-mediated mitochondrial checkpoint regulates quiescence in Drosophila GSCs and human iPSCs through mitophagy and mitochondrial dynamics.

Drought duration determines the recovery dynamics of rice root microbiomes

This study shows that drought duration affects the recovery of rice root microbiomes, with prolonged drought reducing resilience and altering microbial community dynamics.

Single particle-resolution fluorescence microscopy of nanoplastics

This paper develops STED microscopy techniques to image nanoplastics at single-particle resolution, enabling precise localization and quantification in complex environments.

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease

This study compares two dietary models of murine NAFLD/NASH, showing differences in metabolic syndrome and liver disease severity, but similar tumour burdens in liver cancer models.

Stop the crop: insights into the insecticidal mode of action of cinnamodial against mosquitoes

This study identifies the insecticidal mechanism of cinnamodial against mosquitoes by showing it inhibits crop contractility through Ca2+ elevation and tetanic paralysis.

Microbiota stability in healthy individuals after single-dose lactulose challenge - a randomized controlled study

This study examines the effect of a single-dose lactulose challenge on gut microbiota stability and E. coli density in healthy individuals, finding no significant changes in E. coli levels or microbiota composition.

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

The paper identifies how ATF6 activation reduces secretion of a destabilized amyloidogenic protein by enhancing its retention in the ER through specific proteostasis factors.

Social and nutritional factors shape larval aggregation, foraging, and body mass in a polyphagous fly

This study shows that larval aggregation in Bactrocera tryoni is influenced by density and diet concentration, with aggregation aiding growth in high-density environments.

Imprint of parity and age at first birth on the genomic landscape of subsequent breast cancer

This study examines how parity and age at first birth influence the genomic and transcriptomic features of subsequent breast cancer, finding distinct patterns in mutation types and immune infiltration.

Compositional shifts in the root microbiota track the life-cycle of field-grown rice plants

This study tracks root microbiota changes in field-grown rice over its life cycle, showing dynamic shifts during the vegetative phase and correlations with developmental stages rather than age alone.

Scaling up DNA data storage and randomaccess retrieval

This paper demonstrates large-scale DNA data storage with random access, storing 200MB of data in 13 million DNA oligonucleotides and achieving error-free retrieval.