Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP
H. Liu, D. Zakrzewicz, K. Nosol, R. N. Irobalieva, S. Mukherjee, R. Bang-Soerensen, N. Goldmann, S. Kunz, L. Rossi, A. A. Kossiakoff, S. Urban, D. Glebe, J. Geyer, K. P. Locher
The paper determines the cryo-EM structure of bulevirtide bound to NTCP, revealing its mechanism of inhibiting HBV/HDV entry and providing insights for drug development.
bioRxiv · Jan 22, 2024 · PreprintBiochemistry