Author

S. Urban

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

B. Qu· 2 shared F. A. Lempp· 2 shared V. L. Dao Thi· 2 shared X. Wu· 2 shared A. A. Kossiakoff· 1 shared A. Acevedo· 1 shared A. Betz· 1 shared A. L. Cathcart· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

B. Qu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP

H. Liu, D. Zakrzewicz, K. Nosol, R. N. Irobalieva, S. Mukherjee, R. Bang-Soerensen, N. Goldmann, S. Kunz, L. Rossi, A. A. Kossiakoff, S. Urban, D. Glebe, J. Geyer, K. P. Locher

The paper determines the cryo-EM structure of bulevirtide bound to NTCP, revealing its mechanism of inhibiting HBV/HDV entry and providing insights for drug development.

bioRxiv · Jan 22, 2024 · PreprintBiochemistry

Human pluripotent stem cell-derived hepatocyte-like cells for hepatitis D virus studies

H. Chi, B. Qu, A. Prawira, L. Maurer, J. Hu, R. M. Fu, F. A. Lempp, Z. Zhang, D. Grimm, X. Wu, S. Urban, V. L. Dao Thi

This study shows that hepatocyte-like cells derived from human pluripotent stem cells are permissive to hepatitis D virus infection and can be used to study HDV biology and test therapies.

bioRxiv · Oct 13, 2023 · PreprintMicrobiology

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

T.-F. Li, P. Rothhaar, A. Lang, O. Gruenvogel, O. Colasanti, S. M. Olivera Ugarte, J. Traut, A. Piras, N. Acosta-Rivero, V. Goncalves Magalhaes, E. Springer, A. Betz, H.-E. Huang, J. Park, R. Qiu, , V. Lohmann

This study identifies RBM39 as a regulator of innate immunity by controlling transcription and splicing of key interferon response factors, revealing its potential as a therapeutic target.

bioRxiv · Oct 13, 2023 · PreprintImmunology

The potent broadly neutralizing antibody VIR-3434 controls Hepatitis B and D Virus infection and reduces HBsAg in humanized mice

F. A. Lempp, T. Volz, E. Cameroni, F. Benigni, J. Zhou, L. E. Rosen, J. Noack, F. Zatta, H. Kaiser, S. Bianchi, G. Lombardo, S. Jaconi, H. Imam, L. B. Soriaga, N. Passini, , M. A. Schmid

This paper identifies a potent anti-HBs mAb, VIR-3434, that neutralizes HBV and HDV and reduces HBsAg and viremia in human liver-chimeric mice.

bioRxiv · Sep 9, 2022Microbiology

HBV DNA is a substrate for the cGAS/STING pathway but is not sensed in infected hepatocytes

L. Lauterbach-Riviere, M. Bergez, S. Mönch, B. Qu, M. Riess, F. Vondran, J. Liese, V. Hornung, S. Urban, R. Koenig

This study shows HBV DNA is sensed by cGAS/STING in hepatocytes but is not detected during infection due to capsid shielding, while HBV RNAs are not immunostimulatory.

bioRxiv · Dec 6, 2019Microbiology

An RNA-based system to study hepatitis B virus replication and select drug-resistance mutations

Y. Yu, W. M. Schneider, E. Michailidis, A. Acevedo, Y. Ni, P. Ambrose, C. Zou, M. Kabbani, C. Quirk, C. Jahan, X. Wu, S. Urban, A. Shlomai, Y. P. de Jong, C. M. Rice

This paper describes an RNA-based system to study HBV replication and predict drug resistance mutations.

bioRxiv · Oct 2, 2019 · PreprintMicrobiology