Cancer BiologybioRxiv
Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
A. Kulkarni, V. Mohan, T. Tang…·K. F. Harvey
This study identifies resistance mechanisms to TEAD inhibitors by showing MAPK hyperactivation can counteract their effects and suggests combining TEAD and MEK inhibition as a therapeutic strategy.
DOI 10.1038/s44319-024-00217-3