Author

J. Rosenbluh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

H. Sivakumaran· 2 shared J. D. French· 2 shared M. Manning· 2 shared S. Kaufmann· 2 shared S. L. Edwards· 2 shared A. Civitarese· 1 shared A. Hatzipantelis· 1 shared A. Kulkarni· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

H. Sivakumaran

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4 papers

Recent·Most cited

SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss

X. Xi, L. Liu, N. Tuano, J. Tailhades, D. Mouradov, O. Sieber, M. Cryle, E. Segelov, J. Rosenbluh

The paper identifies SRP19 as a vulnerability in cancers with APC loss, showing that reducing SRP19 inhibits proliferation through ER stress.

bioRxiv · Jan 30, 2024 · PreprintCancer Biology

CRISPR-Cas13d screens identify KILR a breast cancer risk-associated lncRNA that regulates DNA replication and repair.

L. Wang, M. Bitar, X. Lu, S. Jacquelin, S. Nair, H. Sivakumaran, K. M. Hillman, S. Kaufmann, R. Ziegman, F. Casciello, H. Gowda, J. Rosenbluh, S. L. Edwards, J. D. French

The paper identifies KILR, a breast cancer risk-associated lncRNA, and shows it regulates DNA replication and repair by sequestering RPA1.

bioRxiv · Nov 16, 2023 · PreprintCancer Biology

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

A. Kulkarni, V. Mohan, T. Tang, L. Post, M. Manning, N. Thio, B. L. Parker, J. Rosenbluh, J. H. A. Vissers, K. F. Harvey

This study identifies resistance mechanisms to TEAD inhibitors by showing MAPK hyperactivation can counteract their effects and suggests combining TEAD and MEK inhibition as a therapeutic strategy.

bioRxiv · Aug 16, 2023Cancer Biology

CRISPR screens identify gene targets and drug repositioning opportunities at breast cancer risk loci

N. K. Tuano, J. Beesley, M. Manning, W. Shi, L. Malver-Ortega, J. Paynter, D. Black, A. Civitarese, K. McCue, A. Hatzipantelis, K. Hillman, S. Kaufmann, H. Sivakumaran, J. M. Polo, R. Reddel, , J. Rosenbluh

bioRxiv · Sep 7, 2021 · PreprintCancer Biology