Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity
X. Luo, K. M. McAndrews, K. A. Arian, S. J. Morse, V. Boeker, S. V. Kumbhar, Y. Hu, K. K. Mahadevan, K. A. Church, S. Chitta, N. T. Ryujin, J. Hensel, J. Dai, D. P. Dowlatshahi, H. Sugimoto, , R. Kalluri
This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.
bioRxiv · Mar 14, 2024Immunology