Author

K. K. Mahadevan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Sugimoto· 3 shared R. Kalluri· 3 shared A. M. Sockwell· 2 shared B. Li· 2 shared K. A. Arian· 2 shared K. M. McAndrews· 2 shared M. L. Kirtley· 2 shared S. J. Morse· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

H. Sugimoto

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Author profile →

3 papers

Recent·Most cited

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

X. Luo, K. M. McAndrews, K. A. Arian, S. J. Morse, V. Boeker, S. V. Kumbhar, Y. Hu, K. K. Mahadevan, K. A. Church, S. Chitta, N. T. Ryujin, J. Hensel, J. Dai, D. P. Dowlatshahi, H. Sugimoto, , R. Kalluri

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

bioRxiv · Mar 14, 2024Immunology

Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

K. K. Mahadevan, A. M. Dyevoich, Y. Chen, B. Li, H. Sugimoto, A. M. Sockwell, K. M. McAndrews, H. Wang, S. Shalapour, S. S. Watowich, R. Kalluri

The paper shows that type-I conventional dendritic cells enhance checkpoint blockade immunotherapy effectiveness in pancreatic cancer when combined with pancreatitis.

bioRxiv · Mar 5, 2023 · PreprintCancer Biology

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

K. K. Mahadevan, K. McAndrews, V. LeBleu, S. Yang, H. Lyu, B. Li, A. M. Sockwell, M. L. Kirtley, S. J. Morse, B. M. Moreno Diaz, M. P. Kim, N. Feng, A. M. Lopez, P. A. Guerrero, H. Sugimoto, , R. Kalluri

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

bioRxiv · Feb 15, 2023 · PreprintCancer Biology