J. H. van Heerden

This paper shows that inhomogeneous cytoplasm organization in E. coli causes growth rate perturbations during cell division, with smaller cells compensating differently than larger ones.

The paper develops a FRET biosensor, yEPAC, to measure cAMP signaling in budding yeast and finds that cAMP peaks vary with nutrient transitions and follow Weber's law.

This study quantifies growth and protein expression dynamics in single B. subtilis cells during the cell cycle, revealing biphasic behavior in growth rate and protein production that compensates for cell division disturbances.

The paper uses statistical theory and real-time imaging data to predict single-cell growth characteristics and develops a simulation algorithm to reduce computational burden.