Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire
P. Altman, G. Ozorowski, R. Stanfield, J. Haakenson, M. Appel, M. Parren, W.-H. Lee, H. Sang, J. Woehl, K. Saye-Francisco, C. Joyce, G. Song, K. Porter, E. Landais, R. Andrabi, , D. Sok
This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.
bioRxiv · Feb 13, 2024Immunology