J. Hartman

Resolvin D2/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation

This study shows RvD2/GPR18 signaling enhances M-MDSC function to reduce AAA formation by suppressing inflammation and vascular remodeling.

Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells

This paper develops a recombinant spider silk-based 3D culture system for breast cancer cells, showing improved cell viability and modulation of cancer-related biological processes.

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans

The paper develops an automated platform to quantify dopaminergic neurodegeneration in C. elegans, showing it detects 19 metrics and validates accuracy against manual scoring.

Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue.

This paper introduces Spatial VDJ, a spatial transcriptomics method that maps T and B cell receptors in human tissue, revealing clonal dynamics and spatial organization of lymphocytes.

Tumoroscope: a probabilistic model for mapping cancer clones in tumor tissues

Tumoroscope maps cancer clones in tumor tissues by integrating spatial transcriptomics, whole exome sequencing, and pathological images to reveal spatial patterns and clone-specific gene expression.

VEGF-C expression in TAMs rewires the metastaticfate of breast cancer cells

This study shows that VEGF-C-expressing TAMs reduce lung metastasis while increasing lymph node metastasis by normalizing tumor blood vessels and promoting lymphangiogenesis.

Predicted distribution of a rare and understudied forest carnivore: Humboldt martens (Martes caurina humboldtensis)

The paper models the distribution of Humboldt martens using environmental variables and identifies habitat associations, highlighting gaps in current knowledge.