A. K. Sharma

Resolvin D2/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation

This study shows RvD2/GPR18 signaling enhances M-MDSC function to reduce AAA formation by suppressing inflammation and vascular remodeling.

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injury

This study shows that MerTK-dependent efferocytosis by monocytic-MDSCs reduces post-lung transplant ischemia-reperfusion injury.

Polymer Model Unveils Quantitative Association of Chromatin Conformation and Gene Regulation

The paper introduces a computational framework linking chromatin structure to gene regulation using polymer models and Hi-C data, showing how CTCF deletion affects gene expression in limb development.

The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.

This study shows that common TMEM173 alleles HAQ and AQ reduce inflammation in SAVI mice by preventing CD4 T cell depletion and restoring T-regs.

A Gallium-68-Labeled Peptide Radiotracer For CD38-Targeted Imaging In Multiple Myeloma With PET

This paper develops a gallium-68-labeled peptide radiotracer, [68Ga]Ga-AJ206, for non-invasive CD38 imaging in multiple myeloma using PET, showing high specificity and utility in monitoring therapy response.

Methylglyoxal controls tomato fruit ripening by regulating ethylene biosynthesis

This study shows that methylglyoxal (MG) regulates tomato fruit ripening by controlling ethylene biosynthesis through the SlGLY14 gene.

A ripening-associated ethylene response factor ERF.D7 activates ARF2 orthologs to regulate tomato fruit ripening

This study identifies SlERF.D7 as a ripening regulator in tomatoes that activates SlARF2A/B to control ripening by integrating auxin and ethylene signaling.

A salt bridge-mediated resistance mechanism to FtsZ inhibitor PC190723 revealed by a cell-based screen

This paper develops a cell-based assay to screen for FtsZ inhibitors and identifies a salt bridge-mediated resistance mechanism to PC190723 in Helicobacter pylori FtsZ.

Functional Biomarkers of Ex-vivo Dental Caries Onset

This study identifies five metabolites associated with the onset of dental caries using an ex-vivo model and metabolomics, linking them to specific bacterial taxa.

Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses

The paper tests tolfenamic acid's toxicity to Gyps vultures and finds it safe at concentrations found in cattle carcasses, unlike other NSAIDs.

Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

This study identifies NSC49L as a PP2A agonist that sensitizes FOLFOX-resistant colorectal cancer cells to TRAIL by downregulating the AKT1/mTOR/4EBP1-axis and p21 translation.

Recombination in Sarbecovirus lineage and mutations/insertions in spike protein linked to the emergence and adaptation of SARS-CoV-2

This study investigates the origin and adaptation of SARS-CoV-2 through recombination events and mutations in the spike protein, linking these factors to its emergence in humans.

Computed tomography reveals hip dysplasiain the extinct Pleistocene saber-tooth cat Smilodon

The paper uses CT scans to analyze hip pathology in a Smilodon fossil, concluding it suffered from hip dysplasia, suggesting social behavior in the species.

A charge-dependent phase transition determines interphase chromatin organization

The paper investigates charge-dependent phase separation in chromatin using electron spectroscopic imaging and shows that chromatin organization changes with histone modifications and environmental factors.

Combinations of slow translating codon clusters can increase mRNA half-life

The paper shows that two slow codon clusters can increase mRNA half-life by suppressing ribosome queues, contrasting the effect of a single cluster.

SCGN Administration prevents Insulin Resistance and Diabetic Complications in High-Fat Diet Fed Animals

This study shows that administering SCGN improves insulin response and alleviates diabetic complications in high-fat diet-fed animals.