Author

J. Heffler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:comparative / phylogenetic analysis· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

B. L. Prosser· 2 shared A. I. Bogush· 1 shared A. Salomon· 1 shared C. S. Corredera· 1 shared D. Amiad Pavlov· 1 shared J. Lammerding· 1 shared K. M. Shen· 1 shared K. Uchida· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

B. L. Prosser

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2 papers

Recent·Most cited

Microtubule forces drive nuclear damage in LMNA cardiomyopathy

D. Amiad Pavlov, J. Heffler, C. S. Corredera, M. Dehghany, K. M. Shen, N. Zuela-Sopilniak, R. Randell, K. Uchida, R. Jain, V. Shenoy, J. Lammerding, B. L. Prosser

This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.

bioRxiv · Feb 10, 2024 · PreprintCell Biology

Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte

A. Salomon, S. A. Phyo, N. Okami, J. Heffler, P. Robison, A. I. Bogush, B. L. Prosser

This study shows that desmin and detyrosination stabilize microtubules at the Z-disk in cardiomyocytes, enhancing cytoskeletal stiffness and contractile function.

bioRxiv · May 26, 2021Cell Biology