V. Shenoy

Microtubule forces drive nuclear damage in LMNA cardiomyopathy

This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

Microinterfaces in bicontinuous hydrogels guide rapid 3D cell migration

This study develops a bicontinuous hydrogel system that enables rapid 3D cell migration by leveraging microinterfaces, showing mesenchymal behavior across multiple contexts.

Active Transcription and Epigenetic Reactions Synergistically RegulateMeso-Scale Genomic Organization

This study introduces a mesoscale model to show how transcription and epigenetic reactions regulate heterochromatin domain sizes, finding that transcription loss increases domain size and compaction.

Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

This study shows breast cancer cells invade the basement membrane using both proteases and mechanical forces from cell volume expansion and local contractility.

FBXO11 deficiency in mice impairs lung development and aggravates cigarette smoke-induced airway fibrosis

This study shows that FBXO11 deficiency in mice leads to impaired lung development and worsens cigarette smoke-induced airway fibrosis by promoting epithelial-mesenchymal transition.

Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner

This study shows vimentin intermediate filaments modulate cell-generated forces depending on microenvironment stiffness, increasing forces on stiff matrices and decreasing them on soft matrices.

Tension anisotropy drives phenotypic transitions of cells via two-way cell-ECM feedback

This study shows that tension anisotropy, not stress amplitude, drives phenotypic transitions of fibroblasts to myofibroblasts through cell-ECM feedback.

Chemo-mechanical Diffusion Waves Orchestrate Collective Dynamics of Immune Cell Podosomes

This study develops a chemo-mechanical model to explain how immune cell podosomes generate oscillatory growth and coordinated wave dynamics through actin polymerization, myosin contractility, and actin diffusion.

Mechanical memory in cells emerges from mechanotransduction with transcriptional feedback and epigenetic plasticity

This paper proposes a theoretical framework explaining long-term mechanical memory in cells by integrating transcriptional feedback and epigenetic plasticity with mechanotransduction.

An Active Chemo-mechanical Model to Predict Adhesion and Microenvironmental Regulation of 3D Cell Shapes

This study develops a chemo-mechanical model to predict how adhesions and microenvironmental properties regulate 3D cell shapes, validated with experiments on HT1080 cells and literature data.

Balance of Mechanical Forces Drives Endothelial Gap Formation and May Facilitate Cancer and Immune-Cell Extravasation

This study shows that mechanical forces drive spontaneous gap formation in endothelial cells, which may facilitate cancer and immune cell extravasation by preferentially occurring at cell vertices.